Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine

被引:30
|
作者
Kaput, Jim
Perlina, Alla
Hatipoglu, Betul
Bartholomew, Amelia
Nikolsky, Yuri
机构
[1] Univ Illinois, Dept Surg, Chicago, IL 60612 USA
[2] European Nutrigenom Org, NuGO, Davis, CA 95616 USA
[3] Univ Calif Davis, NCMHD Ctr Excellence Nutr Genom, Davis, CA 95616 USA
[4] GeneGO, Encinitas, CA 92024 USA
[5] Univ Illinois, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL 60612 USA
关键词
15-dOH-prostaglandin J(2); dietary lipids; nutrigenomics; pharmacogenomics; rosiglitazone; Type; 2; diabetes;
D O I
10.2217/14622416.8.4.369
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The maintenance of health and the prevention and treatment of chronic diseases are influenced by naturally occurring chemicals in foods. in addition to supplying the substrates for producing energy, a large number of dietary chemicals are bioactive -that is, they alter the regulation of biological processes and, either directly or indirectly, the expression of genetic information. Nutrients and bioactives may produce different physiological phenotypes among individuals because of genetic variability and not only alter health, but also disease initiation, progression and severity. The study and application of gene-nutrient interactions is called nutritional genomics or nutrigenomics. Nutrigenomic concepts, research strategies and clinical implementation are similar to and overlap those of pharmacogenomics, and both are fundamental to the treatment of disease and maintenance of optimal health.
引用
收藏
页码:369 / 390
页数:22
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