Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study

被引：3

作者：

Nguimmo-Metsadjio, Aurelie ^{[1
,2
]}

Atogho-Tiedeu, Barbara ^{[1
,2
]}

Noubiap, Jean Jacques ^{[3
,4
,5
]}

Evehe, Marie-Solange ^{[1
,2
]}

Djokam-Dadjeu, Rosine ^{[1
,2
]}

Donfack, Olivier Sontsa ^{[1
,2
]}

Nanfa, Dieudonne ^{[1
,2
]}

Mato, Edith Pascale M. ^{[1
,2
]}

Ngwa, Elvis Ndonwi ^{[1
,2
]}

Guewo-Fokeng, Magellan ^{[1
,2
]}

Pokam-Fosso, Priscille ^{[1
,2
]}

Mbacham, Wilfred F. ^{[1
,6
]}

Mbanya, Jean Claude ^{[2
,7
,8
]}

Sobngwi, Eugene ^{[2
,7
,8
]}

机构：

[1] Univ Yaounde I, Dept Biochem, Fac Sci, Yaounde, Cameroon

[2] Univ Yaounde I, Biotechnol Ctr, Lab Mol Med & Metab, Yaounde, Cameroon

[3] Groote Schuur Hosp, Dept Med, Cape Town, South Africa

[4] Univ Cape Town, Cape Town, South Africa

[5] Med Diagnost Ctr, Yaounde, Cameroon

[6] Univ Yaounde I, Biotechnol Ctr, Lab Publ Hlth Res Biotechnol, Yaounde, Cameroon

[7] Univ Yaounde I, Fac Med & Biomed Sci, Dept Internal Med & Specialties, Yaounde, Cameroon

[8] Yaounde Cent Hosp, Natl Obes Ctr, Yaounde, Cameroon

来源：

JOURNAL OF HEALTH POPULATION AND NUTRITION | 2017年 / 36卷

关键词：

Obesity; Genetic association; TCF7L2; rs7903146 (C/T) polymorphism; Sub-Saharan Africa; Cameroon; TYPE-2; DIABETES-MELLITUS; WAIST CIRCUMFERENCE; URBAN; SERUM; PREVALENCE; VARIANT;

D O I：

10.1186/s41043-017-0087-z

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. Method: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. Results: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. Conclusion: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.

引用

页数：6

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