The role of heat shock proteins in metastatic colorectal cancer: A review

被引：19

作者：

Javid, Hossein ^{[1
,2
]}

Hashemian, Pedram ^{[3
]}

Yazdani, Shaghayegh ^{[4
,5
]}

Mashhad, Alireza Sharbaf ^{[4
]}

Karimi-Shahri, Mehdi ^{[6
,7
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Razavi Khorasan, Iran

[2] Varastegan Inst Med Sci, Dept Med Lab Sci, Mashhad, Razavi Khorasan, Iran

[3] Jahad Daneshgahi Inst, Jahad Daneshgahi Res Comm, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Dept Med Lab Sci, Mashhad, Razavi Khorasan, Iran

[5] Ilam Univ Med Sci, Dept Med Lab Sci, Ilam, Iran

[6] Mashhad Univ Med Sci, Sch Med, Dept Pathol, Mashhad, Razavi Khorasan, Iran

[7] Gonabad Univ Med Sci, Sch Med, Dept Pathol, Gonabad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2022年 / 123卷 / 11期

关键词：

colorectal cancer (CRC); heat shock proteins (HSPs); metastatic colorectal cancer; ALPHA-B-CRYSTALLIN; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; COLON-CANCER; BETA-CATENIN; TUMOR-SUPPRESSOR; THERAPEUTIC TARGET; BREAST-CANCER; CELL-CYCLE; HEAT-SHOCK-PROTEIN-60; HSP60;

D O I：

10.1002/jcb.30326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.

引用

页码：1704 / 1735

页数：32

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