Synthesis and molecular docking of novel N-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine derivatives as anti-HIV-1 reverse transcriptase inhibitors

被引：1
|
作者：
Fazlinezhad, Maassoumeh [1 ]
Nakhaei, Ahmad [2 ]
Eshghi, Hossein [3 ]
Saadatmandzadeh, Mohammad [3 ]
机构：
[1] Payame Noor Univ, Dept Chem, Tehran 193953697, Iran
[2] Islamic Azad Univ, Mashhad Branch, Young Researchers & Elite Club, Mashhad, Razavi Khorasan, Iran
[3] Ferdowsi Univ Mashhad, Fac Sci, Chem Dept, Mashhad, Razavi Khorasan, Iran
来源：
EURASIAN CHEMICAL COMMUNICATION | 2019年 / 1卷 / 02期
关键词：
N-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine; mlecular docking; p-toluidine; 2-chloroquinoline-3-carbaldehyde; anti-HIV; Vilsmeier-Haack reagent;
D O I：
10.33945/SAMI/ECC.2019.2.1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this research work, a proficient method has been developed for the preparation of novel N-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine derivatives from 2-chloroquinoline-3-carbaldehyde derivatives and p-toluidine in ethanol as solvent and using catalytic amount of acetic acid under reflux conditions to obtain desired products in good yields. The identification of all the synthesized compounds was confirmed by melting point, FT-IR, H-1 NMR, and C-13 NMR. Also, in the present work, all the synthesized compounds were evaluated for their molecular docking as anti-HIV-1 reverse transcriptase inhibitors using GOLD 5.2. software. The results of molecular docking showed that all the compounds established 'pi-pi' interactions with side chain of amino acid.
引用
收藏
页码：125 / 133
页数：9
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