Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS

被引：31
|
作者：
Dell'Albani, P
Santangelo, R
Torrisi, L
Nicoletti, VG
Stella, AMG
机构：
[1] CNR, Inst Neurol Sci, I-95123 Catania, Italy
[2] Univ Catania, Dept Chem Sci, Biochem & Mol Biol Sect, I-95125 Catania, Italy
来源：
NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 01期
关键词：
JAKs; STATs; signal transduction; CNS; gene expression;
D O I：
10.1023/A:1021644027850
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).
引用
收藏
页码：53 / 64
页数：12
相关论文
共 50 条
  • [21] Negative regulation of the JAK/STAT pathway
    Starr, R
    Hilton, DJ
    BIOESSAYS, 1999, 21 (01) : 47 - 52
  • [22] The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    Donnelly, RP
    Dickensheets, H
    Finbloom, DS
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (06): : 563 - 573
  • [23] Interleukin-11 promotes osteoblast differentiation via JAK/STAT signal transduction pathway
    Shih, C
    Lai, JH
    BONE, 2001, 28 (05) : S156 - S156
  • [24] The signal transduction mediated by erythropoietin and proinflammatory cytokines in the JAK/STAT pathway in the children with cerebral palsy
    Tao, Weiyuan
    Wen, Fang
    Zhang, Hong
    Liu, Guheng
    BRAIN & DEVELOPMENT, 2009, 31 (03): : 200 - 207
  • [25] RETRACTION: Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia
    Li, Junguo
    Zhang, Li
    Li, Bing
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2025, 29 (04)
  • [26] FGF signal transduction and the regulation of Cdx gene expression
    Keenan, Iain D.
    Sharrard, R. Michael
    Isaacs, Harry V.
    DEVELOPMENTAL BIOLOGY, 2006, 299 (02) : 478 - 488
  • [27] A MAJOR ROLE FOR THE PROTEIN-TYROSINE KINASE JAK1 IN THE JAK/STAT SIGNAL-TRANSDUCTION PATHWAY IN RESPONSE TO INTERLEUKIN-6
    GUSCHIN, D
    ROGERS, N
    BRISCOE, J
    WITTHUHN, B
    WATLING, D
    HORN, F
    PELLEGRINI, S
    YASUKAWA, K
    HEINRICH, P
    STARK, GR
    IHLE, JN
    KERR, IM
    EMBO JOURNAL, 1995, 14 (07): : 1421 - 1429
  • [28] Role of JAK/STAT Signal Pathway in Con A-induced Autoimmune Hepatitis
    Li Sha
    Ma Li-Jie
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2016, 43 (12) : 1139 - 1145
  • [29] Novel aspects of JAK/STAT pathway regulation
    不详
    JOURNAL OF CELL SCIENCE, 2020, 133 (19)
  • [30] SOCS regulation of the JAK/STAT signalling pathway
    Croker, Ben A.
    Kiu, Hiu
    Nicholson, Sandra E.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (04) : 414 - 422
12345