Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder

被引：7

作者：

Pongsamart, Kasama ^{[1
]}

Limwikrant, Waree ^{[1
]}

Ruktanonchai, Uracha Rungsardthong ^{[3
]}

Charoenthai, Nattawut ^{[1
,2
]}

Puttipipatkhachorn, Satit ^{[1
,2
,4
]}

机构：

[1] Mahidol Univ, Fac Pharm, Dept Mfg Pharm, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Pharm, Ctr Innovat Pharm Pharmaceut & Herbal Prod Dev, Bangkok 10400, Thailand

[3] Natl Nanotechnol Ctr, Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand

[4] Mahidol Univ, Dept Mfg Pharm, Fac Pharm, 447 Sri Ayudhya Rd, Bangkok 10400, Thailand

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2022年 / 73卷

关键词：

Dihydroartemisinin; beta-cyclodextrin; Spray drying; Inclusion complex; Antimalarial activity; SOLID DISPERSIONS; PHARMACEUTICAL APPLICATIONS; DISSOLUTION CHARACTERISTICS; PHYSICAL STABILITY; PROCESS VARIABLES; DRUG SOLUBILITY; COMPLEXATION; BIOAVAILABILITY; ENHANCEMENT; ARTEETHER;

D O I：

10.1016/j.jddst.2022.103434

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study a factorial design was used to optimize process conditions to produce spray-dried powder of dihydroartemisinin (DHA) with beta-cyclodextrin (beta-CD). Predicted conditions for maximum yield and minimum residual moisture were as follows: inlet temperature; 120 C, aspirator setting; 100%, feed rate; 25%, and molar ratio of DHA:beta-CD; 1:2. The higher percent inclusion yield was obtained in the spray-dried powder with lower molar ratio of DHA:beta-CD. DHA existed in amorphous state in the spray-dried powder with 1:2 M ratio of DHA:beta-CD whereas it was in crystalline state in the spray-dried powder with 2:1 M ratio of DHA:beta-CD. The inclusion complex formation between DHA and beta-CD was revealed by FTIR study. The spray-dried powder of DHA with beta-CD showed dramatically enhanced dissolution rate with unchanged antimalarial activity. Moreover, it was chemically and physically stable at 30 C, 75%RH for 3 months after storage.

引用

页数：9

共 50 条

[1] Characterization of crystalline and spray-dried amorphous α-cyclodextrin powders
Ho, Thao M.
Howes, Tony
Bhandari, Bhesh R.
POWDER TECHNOLOGY, 2015, 284 : 585 - 594
[2] Preparation and characterization of spray-dried polymeric nanocapsules
Müller, CR
Bassani, VL
Pohlmann, AR
Michalowski, CB
Petrovick, PR
Guterres, SS
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2000, 26 (03) : 343 - 347
[3] Spray-dried chitinosans - Part I: preparation and characterization
Rege, PR
Garmise, RJ
Block, LH
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 252 (1-2) : 41 - 51
[4] Preparation and characterization of spray-dried oxidized cellulose microparticles
Kumar, V
Kang, JC
Yang, TR
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2001, 6 (03) : 449 - 458
[5] Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac
Nagda, Chirag
Chotai, Narendra Prabhudas
Patel, Upendra
Patel, Sandip
Soni, Tejal
Patel, Prateek
Hingorani, Lal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2009, 35 (10) : 1155 - 1166
[6] Development and Characterization of a Nutritionally Rich Spray-Dried Honey Powder
Suhag, Yogita
Nayik, Gulzar Ahmad
Karabagias, Ioannis K.
Nanda, Vikas
FOODS, 2021, 10 (01)
[7] The structure and properties of spray-dried powder
Yoshii, H. (foodeng.yoshii@ag.kagawa-u.ac.jp), 1600, Japan Society for Food Engineering (14):
[8] CAKING OF SPRAY-DRIED AVOCADO POWDER
SANTOS, SCS
CALVIDAL, J
PESQUISA AGROPECUARIA BRASILEIRA, 1985, 20 (05) : 615 - 620
[9] Spray-dried rose hip powder
Charley, VLS
Pollard, A
NATURE, 1943, 152 : 354 - 355
[10] The Production of a Spray-Dried Pineapple Powder
Mujaffar, S.
Dhun, G.
III INTERNATIONAL CONFERENCE ON POSTHARVEST AND QUALITY MANAGEMENT OF HORTICULTURAL PRODUCTS OF INTEREST FOR TROPICAL REGIONS, 2014, 1047 : 315 - 322

← 1 2 3 4 5 →