New technologies for high-throughput screening

被引：99
|
作者：
Burbaum, JJ [1 ]
Sigal, NH [1 ]
机构：
[1] Pharmacopeia Inc, Princeton, NJ 08540 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(97)80111-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To screen efficiently the millions of compounds that are synthesized using combinatorial and automated methods, dramatically improved assay technologies are currently needed. In 96-well microtiter plates, nonradioactive techniques (primarily fluorimetric) and cell-based functional methods have moved to the cutting edge, while clever assays that extract information from large bead-based combinatorial libraries have begun to show considerable promise. In the future, miniaturized assays that break out of the 96-well format will be enabled by innovative technologies for high-throughput screening.
引用
收藏
页码：72 / 78
页数：7
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