Rat hepatic CYP1A1 and CYP1A2 induction by menadione

被引：9
|
作者：
Sidorova, YA [1 ]
Grishanova, AY [1 ]
Lyakhovich, VV [1 ]
机构：
[1] Russian Acad Med Sci, Inst Mol Biol & Biophys, Siberian Div, Novosibirsk 630090, Russia
来源：
TOXICOLOGY LETTERS | 2005年 / 155卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
menadione; CYP1A1; CYP1A2; induction in vivo;
D O I：
10.1016/j.toxlet.2004.10.001
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The effects of menadione on activities and expression of cytochrome P45.0 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approximately 5.4- and 2.5-fold increase over control values for ethoxyresorufin-O-deethylase (EROD, CYP1A1) and methoxyresorufin-O-demethylase (MROD, CYP1A2) activities, respectively. CYP1A1 and CYP1A2 mRNA levels in the liver of menadione-treated rats were approximately 11.8- and 1.8-fold higher than in controls, respectively, whereas the expression of the CYP1A regulatory proteins aryl hydrocarbonreceptor (AhR) and AhR nuclear translocator (Arnt) was not changed at the mRNA level. The result of this study demonstrates that menadione induces CYP1A1/1A2 expression in vivo through either transcriptional activation and/or mRNA stabilization. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：253 / 258
页数：6
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