Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines

被引：16
|
作者：
Kato, Naoya [1 ,2 ]
Shirai, Tomohiko [1 ,2 ]
Yamamoto, Yasunori [1 ,2 ]
机构：
[1] Hokkaido Univ, Div Chem Proc Engn, Kita Ku, Kita 13 Nishi 8, Sapporo, Hokkaido 0608628, Japan
[2] Hokkaido Univ, Fac Engn, FCC, Kita Ku, Kita 13 Nishi 8, Sapporo, Hokkaido 0608628, Japan
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 23期
关键词：
asymmetric arylation; cationic rhodium; imines; phosphoramidite; alpha-branched amine; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; N-SULFONYL KETIMINES; ARYLBORONIC ACIDS; ASYMMETRIC ADDITION; ME-BIPAM; CYCLIC KETIMINES; NPS R-568; CALCIMIMETIC AGENT; (+)-NPS R-568; AMINES;
D O I：
10.1002/chem.201601246
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched a-branched amines (up to 99% ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.
引用
收藏
页码：7739 / 7742
页数：4
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