Caenorhabditis elegans Life Span Studies: The Challenge of Maintaining Synchronous Cohorts

被引：3

作者：

Gruber, Jan ^{[1
]}

Poovathingal, Suresh Kumar ^{[2
]}

Schaffer, Sebastian ^{[1
]}

Ng, Li Fang ^{[1
]}

Gunawan, Rudiyanto ^{[2
]}

Halliwell, Barry ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, Neurobiol & Ageing Programme, Yong Loo Lin Sch Med, Singapore 119077, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore, Singapore

来源：

REJUVENATION RESEARCH | 2010年 / 13卷 / 2-3期

关键词：

NEMATODE;

D O I：

10.1089/rej.2009.0943

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Due to its many advantages, the nematode worm Caenorhabditis elegans (C. elegans) is commonly employed as a convenient model for aging studies as well as for testing life span effects of chemical compounds. However, some challenges exist in the context of such life span studies, particularly in relation to generation and maintenance of synchronized cohorts, and these challenges are not always fully appreciated. Here we discuss the impact of incomplete control of nematode proliferation on life span studies and suggest some solutions to minimize these artefacts.

引用

页码：347 / 349

页数：3

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