Xanthones isolated from Gentianella acuta and their protective effects against H2O2-induced myocardial cell injury

被引：14

作者：

Wang, Zhibin ^{[1
]}

Wu, Gaosong ^{[1
]}

Yu, Ying ^{[1
]}

Liu, Hua ^{[1
]}

Yang, Bingyou ^{[1
]}

Kuang, Haixue ^{[1
]}

Wang, Qiuhong ^{[2
]}

机构：

[1] Heilongjiang Univ Chinese Med, Minist Educ, Key Lab Chinese Mat Med, Harbin, Heilongjiang, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 18期

基金：

高等学校博士学科点专项科研基金;

关键词：

Gentianella acuta; xanthones; cardiomyocytes oxidative injury; cytotoxic activity; REPERFUSION INJURY; IN-VIVO; ANTIOXIDANT; GLUCOSIDES; APOPTOSIS; PLANT;

D O I：

10.1080/14786419.2017.1371157

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present study, two new xanthones, (5S,8S)-1,3,5,8-tetrahydroxyxanthone(72)-1,3,5,8-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1), 5-hydroxy-3,4,6-trimethoxyxanthone-1-O--D-glucopyranoside (2), and eight known xanthones (3-10) were isolated from the whole plants of Gentianella acuta. Their structures were identified by the spectroscopic analyses (HR-ESI-MS, and 1D and 2D NMR). Meanwhile, cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury and cytotoxic activities of compounds 1-10 were also determined. [GRAPHICS] .

引用

页码：2171 / 2177

页数：7

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