Xanthones isolated from Gentianella acuta and their protective effects against H2O2-induced myocardial cell injury

被引：14
|
作者：
Wang, Zhibin [1 ]
Wu, Gaosong [1 ]
Yu, Ying [1 ]
Liu, Hua [1 ]
Yang, Bingyou [1 ]
Kuang, Haixue [1 ]
Wang, Qiuhong [2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Minist Educ, Key Lab Chinese Mat Med, Harbin, Heilongjiang, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 18期
基金：
高等学校博士学科点专项科研基金;
关键词：
Gentianella acuta; xanthones; cardiomyocytes oxidative injury; cytotoxic activity; REPERFUSION INJURY; IN-VIVO; ANTIOXIDANT; GLUCOSIDES; APOPTOSIS; PLANT;
D O I：
10.1080/14786419.2017.1371157
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In the present study, two new xanthones, (5S,8S)-1,3,5,8-tetrahydroxyxanthone(72)-1,3,5,8-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1), 5-hydroxy-3,4,6-trimethoxyxanthone-1-O--D-glucopyranoside (2), and eight known xanthones (3-10) were isolated from the whole plants of Gentianella acuta. Their structures were identified by the spectroscopic analyses (HR-ESI-MS, and 1D and 2D NMR). Meanwhile, cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury and cytotoxic activities of compounds 1-10 were also determined. [GRAPHICS] .
引用
收藏
页码：2171 / 2177
页数：7
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