Synthesis and immobilization of ceramide analogs on silica particles

被引：18
|
作者：
Yin, JM [1 ]
Liu, HL [1 ]
Pidgeon, C [1 ]
机构：
[1] Purdue Univ, Sch Pharm, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0960-894X(97)10217-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ceramides are the major lipid components of the stratum corneum, the major permeability barrier of the skin. Here we report a chemical synthesis of ceramide analogs covalently bonded on the silica particles, that can be used to predict the skin permeability of chemicals via HPLC methods. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：179 / 182
页数：4
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