Prompt and Successful Toxin-Targeting Treatment of Three Patients with Necrotizing Pneumonia Due to Staphylococcus aureus Strains Carrying the Panton-Valentine Leukocidin Genes

被引：50

作者：

Rouzic, Nicolas ^{[1
,2
,3
,4
]}

Janvier, Frederic ^{[5
,6
]}

Libert, Nicolas ^{[6
,7
]}

Javouhey, Etienne ^{[8
]}

Lina, Gerard ^{[1
,2
,3
,4
]}

Nizou, Jacques-Yves ^{[5
,6
]}

Pasquier, Pierre ^{[9
]}

Stamm, Didier ^{[8
]}

Brinquin, Louis ^{[6
,7
]}

Pelletier, Christophe ^{[9
]}

Vandenesch, Francois ^{[1
,2
,3
,4
]}

Floret, Daniel ^{[8
]}

Etienne, Jerome ^{[1
,2
,3
,4
]}

Gillet, Yves ^{[1
,2
,3
,4
,8
]}

机构：

[1] Univ Lyon, F-69008 Lyon, France

[2] Univ Lyon 1, Fac Lyon Est, F-69008 Lyon, France

[3] Ctr Natl Reference Staphylocoques, Inserm EU851, F-69008 Lyon, France

[4] Hosp Civils Lyon, Ctr Biol Est, F-69500 Bron, France

[5] Hop Instruct Armees Val Grace, Serv Biol Med, Paris, France

[6] Ecole Val Grace, Paris, France

[7] Hop Instruct Armees Val Grace, Serv Reanimat, Paris, France

[8] Hop Femme Mere Enfant, Serv Urgences & Reanimat Pediat, Bron, France

[9] Hop Instruct Armees Begin, Serv Reanimat, St Mande, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 05期

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; INFLUENZA SEASON; ANTIBIOTICS; MORTALITY;

D O I：

10.1128/JCM.01892-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three patients with extensive necrotizing pneumonia due to Panton-Valentine leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3 x 10(9)/liter in all three cases and hemoptysis in two cases) were successfully treated with toxin-suppressing agents introduced rapidly after hospital admission.

引用

页码：1952 / 1955

页数：4

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