4,6-Disubstituted quinazoline derivatives as inhibitors of the MEK5/ERK5 pathway

被引:0
|
作者
Patel, Saloni [1 ]
Motta, Austin [1 ]
Flaherty, Patrick [1 ]
Bhatt, Akshita [2 ]
Wright, Thomas [2 ]
Cavanaugh, Jane [2 ]
机构
[1] Duquesne Univ, Med Chem, Pittsburgh, PA 15219 USA
[2] Duquesne Univ, Pharmacol, Pittsburgh, PA 15219 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
128
引用
收藏
页数:1
相关论文
共 50 条
  • [21] A network-based drug prioritization and combination analysis for the MEK5/ERK5 pathway in breast cancer
    Odongo, Regan
    Demiroglu-Zergeroglu, Asuman
    Cakir, Tunahan
    BIODATA MINING, 2024, 17 (01)
  • [22] SPECIFICAL INTERACTIONS BETWEEN NEWLY IDENTIFIED HUMAN KINASES, MEK5 AND ERK5
    ZHOU, GC
    BAO, A
    GUAN, KL
    DIXON, JE
    FASEB JOURNAL, 1995, 9 (06): : A1306 - A1306
  • [23] Analysis of aryl substitution and intramolecular ligand H-bonding in selective inhibitors of the MEK5/ERK5 cascade
    Flaherty, Patrick T.
    Cavanaugh, Jane C.
    Gupta, Mohit
    Vechery, Colin
    Chakrabarty, Suravi
    Monlish, Darlene
    Wright, Thomas
    CANCER RESEARCH, 2015, 75
  • [24] MEK5/ERK5 signaling: Regulation of smooth muscle A-actin promoter activity
    Kaplan-Albuquerque, N
    Nemenoff, RA
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 69A - 70A
  • [25] MEK5/ERK5 Signaling Modulates Endothelial Cell Migration and Focal Contact Turnover
    Spiering, Desiree
    Schmolke, Mirco
    Ohnesorge, Nils
    Schmidt, Marc
    Goebeler, Matthias
    Wegener, Joachim
    Wixler, Viktor
    Ludwig, Stephan
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (37) : 24972 - 24980
  • [26] MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2
    Carter, Emma J.
    Cosgrove, Ruth A.
    Gonzalez, Ivelisse
    Eisemann, Joan H.
    Lovett, Fiona A.
    Cobb, Laura J.
    Pell, Jennifer M.
    JOURNAL OF CELL SCIENCE, 2009, 122 (17) : 3104 - 3112
  • [27] Activation of the MEK5/Erk5 MAP kinase signalling pathway elicits a vasoprotective phenotype in primary human endothelial cells
    Ohnesorge, N.
    Endres, N.
    Viemann, D.
    Spiering, D.
    Roth, J.
    Ludwig, S.
    Goebeler, M.
    Schmidt, M.
    EXPERIMENTAL DERMATOLOGY, 2009, 18 (03) : 322 - 322
  • [28] MEK5/ERK5 activation regulates colon cancer stem-like cell properties
    Diane M. Pereira
    Sofia. E. Gomes
    Pedro M. Borralho
    Cecília M. P. Rodrigues
    Cell Death Discovery, 5
  • [29] Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer
    Sanchez-Fdez, Adrian
    Re-Louhau, Maria Florencia
    Rodriguez-Nunez, Pablo
    Ludena, Dolores
    Matilla-Almazan, Sofia
    Pandiella, Atanasio
    Esparis-Ogando, Azucena
    NPJ PRECISION ONCOLOGY, 2021, 5 (01)
  • [30] Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer
    Adrián Sánchez-Fdez
    María Florencia Re-Louhau
    Pablo Rodríguez-Núñez
    Dolores Ludeña
    Sofía Matilla-Almazán
    Atanasio Pandiella
    Azucena Esparís-Ogando
    npj Precision Oncology, 5