Oncological role of HMGA2 (Review)

被引：120
|
作者：
Zhang, Shizhen [1 ,2 ,3 ]
Mo, Qiuping [2 ,3 ]
Wang, Xiaochen [1 ]
机构：
[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Breast Surg, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Oncol, Hangzhou 310009, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Inst Canc, Hangzhou 310009, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2019年 / 55卷 / 04期
关键词：
high mobility group A2; carcinogenesis; DNA repair; epithelial mesenchymal transition; senescence; MOBILITY GROUP A2; EPITHELIAL-MESENCHYMAL TRANSITION; AT-HOOK; STALLED REPLICATION FORKS; LYMPH-NODE METASTASIS; PROTECTS CANCER-CELLS; DNA-REPAIR MECHANISMS; DOUBLE-STRAND BREAK; CELLULAR SENESCENCE; TRANSCRIPTION FACTOR;
D O I：
10.3892/ijo.2019.4856
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The high mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor that modulates the transcription of several genes by binding to AT-rich sequences in the minor groove of B-form DNA and alters the chromatin structure. As a result, HMGA2 influences a variety of biological processes, including the cell cycle process, DNA damage repair process, apoptosis, senescence, epithelial-mesenchymal transition and telomere restoration. In addition, the overexpression of HMGA2 is a feature of malignancy, and its elevated expression in human cancer predicts the efficacy of certain chemotherapeutic agents. Accumulating evidence has suggested that the detection of HMGA2 can be used as a routine procedure in clinical tumour analysis.
引用
收藏
页码：775 / 788
页数：14
相关论文
共 50 条
  • [31] Hmga2 promoter analysis in transgenic mice
    Schiltz, JF
    Rustighi, A
    Tessari, MA
    Liu, J
    Braghetta, P
    Sgarra, R
    Stebel, M
    Bressan, GM
    Altruda, F
    Giancotti, V
    Chada, K
    Manfioletti, G
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (04) : 718 - 723
  • [32] Convexity dural chondroma with expression of HMGA2
    Sugiura, Y.
    Nagaishi, M.
    Takano, I.
    Tanaka, Y.
    Suzuki, K.
    Hyodo, A.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 357 : E184 - E185
  • [33] Identification and developmental expression of Xenopus hmga2β
    Benini, Francesca
    Onorati, Marco
    Altamura, Sandro
    Manfioletti, Guidalberto
    Vignali, Robert
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (02) : 392 - 397
  • [34] The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3′UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2
    Yuan Wang
    Fuquan Chen
    Zhe Yang
    Man Zhao
    Shuqin Zhang
    Yuen Gao
    Jinyan Feng
    Guang Yang
    Weiying Zhang
    Lihong Ye
    Xiaodong Zhang
    Scientific Reports, 7
  • [35] HMGA2 as single marker for thyroid carcinomas
    Belge, Gazanfer
    Meyer, Anke
    Klemke, Markus
    Burchardt, Kaete
    Stern, Corinna
    Wosniok, Werner
    Loeschke, Siegfried
    Bullerdiek, Joern
    VIRCHOWS ARCHIV, 2008, 452 : S73 - S74
  • [36] Fusion of the HMGA2 and NFIB genes in lipoma
    M. Nilsson
    I. Panagopoulos
    F. Mertens
    N. Mandahl
    Virchows Archiv, 2005, 447 : 855 - 858
  • [37] Fusion of the HMGA2 and NFIB genes in lipoma
    Nilsson, M
    Panagopoulos, I
    Mertens, F
    Mandahl, N
    VIRCHOWS ARCHIV, 2005, 447 (05) : 855 - 858
  • [38] Relationship between the HMGA2 gene and hepatocarcinogenesis
    Koh, Noritoshi
    Tamori, Akihiro
    Habu, Daiki
    Shiomi, Susumu
    Kubo, Shoji
    Shimomura, Soji
    Iijima, Hiroko
    Nakamura, Hideji
    Nishiguchi, Shuhei
    HEPATOLOGY, 2006, 44 (04) : 530A - 530A
  • [39] Hmga2 translocation induces skin tumorigenesis
    Pi, X.
    Boland, K.
    Lad, S.
    Verfaillie, C.
    Morris, R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (05) : S15 - S15
  • [40] HMGA2 expression as a biomarker for aggressive angiomyxoma
    Medeiros, F.
    Oliveira, A. M.
    Lloyd, R. V.
    Jin, L.
    Erickson-Johnson, M.
    Wang, X.
    Quade, B. J.
    MODERN PATHOLOGY, 2008, 21 : 214A - 214A
12345