Oncological role of HMGA2 (Review)

被引：120

作者：

Zhang, Shizhen ^{[1
,2
,3
]}

Mo, Qiuping ^{[2
,3
]}

Wang, Xiaochen ^{[1
]}

机构：

[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Breast Surg, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Oncol, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Inst Canc, Hangzhou 310009, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2019年 / 55卷 / 04期

关键词：

high mobility group A2; carcinogenesis; DNA repair; epithelial mesenchymal transition; senescence; MOBILITY GROUP A2; EPITHELIAL-MESENCHYMAL TRANSITION; AT-HOOK; STALLED REPLICATION FORKS; LYMPH-NODE METASTASIS; PROTECTS CANCER-CELLS; DNA-REPAIR MECHANISMS; DOUBLE-STRAND BREAK; CELLULAR SENESCENCE; TRANSCRIPTION FACTOR;

D O I：

10.3892/ijo.2019.4856

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The high mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor that modulates the transcription of several genes by binding to AT-rich sequences in the minor groove of B-form DNA and alters the chromatin structure. As a result, HMGA2 influences a variety of biological processes, including the cell cycle process, DNA damage repair process, apoptosis, senescence, epithelial-mesenchymal transition and telomere restoration. In addition, the overexpression of HMGA2 is a feature of malignancy, and its elevated expression in human cancer predicts the efficacy of certain chemotherapeutic agents. Accumulating evidence has suggested that the detection of HMGA2 can be used as a routine procedure in clinical tumour analysis.

引用

页码：775 / 788

页数：14

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