The ontogeny of induction of c-fos in the rat SCN by a 5-HT2A/2C agonist

被引：10
|
作者：
Ferguson, SA [1 ]
Kennaway, DJ [1 ]
机构：
[1] Univ Adelaide, Sch Med, Dept Obstet & Gynaecol, Adelaide, SA 5005, Australia
来源：
DEVELOPMENTAL BRAIN RESEARCH | 2000年 / 121卷 / 02期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
development; serotonin; c-fos; circadian rhythms; suprachiasmatic nucleus;
D O I：
10.1016/S0165-3806(00)00042-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The induction of c-fos in the suprachiasmatic nucleus (SCN) by the 5-HT2A/2C agonist, DOI was studied at mid-dark in neonatal rats. The number of cells expressing c-FOS immunoreactivity following DOI was low 3 days after birth, but increased rapidly over the next 3 days. By contrast, light exposure stimulated cells throughout this period. These results are consistent with the arrival of serotonergic afferents at the SCN and their role in the entrainment of rhythms. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：229 / 231
页数：3
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