Synthesis of Indolo[2,1-a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

被引：15
|
作者：
Lee, Ha Kyeong [1 ]
Pham Duy Quang Dao [1 ]
Kim, Young-su [2 ]
Cho, Chan Sik [1 ]
机构：
[1] Kyungpook Natl Univ, Dept Appl Chem, 80 Daehakro, Bukgu 41566, Daegu, South Korea
[2] Kyungdong Univ, Sch Hotel Culinary, Sokcho 217711, South Korea
来源：
SYNTHESIS-STUTTGART | 2018年 / 50卷 / 16期
基金：
新加坡国家研究基金会;
关键词：
copper; coupling; cyclization; heterocycles; fused-ring systems; CARBONYLATIVE CYCLIZATION; CARBOXYLIC-ACIDS; ARYLATION; DERIVATIVES; EFFICIENT;
D O I：
10.1055/s-0036-1591589
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(2-Bromoaryl)-1H-indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1-a]isoquinolines in moderate to good yields.
引用
收藏
页码：3243 / 3249
页数：7
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