Recent Advances of LncRNA H19 in Diabetes LncRNA H19 in Diabetes

被引:16
|
作者
Bi, Ye [1 ]
Wang, Yao [2 ]
Sun, Xianglan [1 ]
机构
[1] Shandong First Med Univ, Dept Geriatr, Jinan, Peoples R China
[2] Med Univ, Shandong Inst Endocrine & Metab Dis, Jinan, Peoples R China
关键词
diabetes mellitus; LncRNA H19; H19; function; LONG NONCODING RNAS; EPIGENETIC ALTERATIONS; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; IGF2; GENE; EXPRESSION; GLUCOSE; METHYLATION; APOPTOSIS; MALAT1;
D O I
10.1055/a-1769-5032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes mellitus (DM) causes damage to major organs, including the heart, liver, brain, kidneys, eyes, and blood vessels, threatening the health of the individuals. Emerging evidence has demonstrated that lncRNAs has important functions in the pathogenesis of human diseases, such as cancers, neurodegenerative diseases, cardiac fibroblast phenotypes, hypertension, heart failure, atherosclerosis and diabetes. Recently, H19, a lncRNA, has been reported to shown to participate in the regulatory process of muscle differentiation, glucose metabolism, and tumor metastasis, as well as endometrial development. However, the roles of H19 in DM were still not completely understood. This review was conducted to summarize the functions of H19 in diabetes and discuss the challenges and possible strategies of H19 in DM.
引用
收藏
页码:212 / 219
页数:8
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