Pharmacodynamic Response to Oral Administration of the Selective Toll-like Receptor 8 Agonist GS-9688 in Healthy Volunteers

被引:0
|
作者
Grant, Ethan [1 ]
Joshi, Adarsh [2 ]
Ayithan, Natarajan [3 ]
Daffis, Stephane [4 ]
Woo, Jacky [5 ]
Lam, Tina [6 ]
Mackman, Richard L. [7 ]
Fletcher, Simon [4 ]
Gaggar, Anuj [5 ]
Lau, Audrey H. [8 ]
Kottilil, Shyamasundaran [3 ]
Poonia, Bhawna [3 ]
机构
[1] Gilead Sci Inc, Biomarker Sci, 353 Lakeside Dr, Foster City, CA 94404 USA
[2] Gilead Sci Inc, Biostat, 353 Lakeside Dr, Foster City, CA 94404 USA
[3] Univ Maryland, Sch Med, Inst Human Virol, Div Clin Care & Res, Baltimore, MD 21201 USA
[4] Gilead Sci Inc, Virol, 353 Lakeside Dr, Foster City, CA 94404 USA
[5] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA
[6] Gilead Sci Inc, Biomarker Operat, 353 Lakeside Dr, Foster City, CA 94404 USA
[7] Gilead Sci Inc, Med Chem, 353 Lakeside Dr, Foster City, CA 94404 USA
[8] Gilead Sci Inc, Clin Res, 353 Lakeside Dr, Foster City, CA 94404 USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
456
引用
收藏
页码:270A / 270A
页数:1
相关论文
共 50 条
  • [41] Contribution of interferon-β to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide
    Thomas, Karen E.
    Galligan, Carole L.
    Newman, Raj Deonarain
    Fish, Eleanor N.
    Vogel, Stefanie N.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (41) : 31119 - 31130
  • [42] EXAGGERATED RESPONSE TO TOLL-LIKE RECEPTOR AGONIST CONTRIBUTES TO EXCESSIVE TNF PRODUCTION IN MYELOPROLIFERATIVE NEOPLASM
    Fleischman, Angela
    Luty, Samuel
    Edmiston, Blair
    LaTocha, Dorian
    Bagby, Grover
    Druker, Brian
    EXPERIMENTAL HEMATOLOGY, 2013, 41 (08) : S57 - S57
  • [43] Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm
    Lai, Hew Yeng
    Morse, Sarah J.
    Luty, Samuel B.
    Garbati, Michael R.
    Edmiston, J. Blair
    Bagby, Grover C.
    Druker, Brian J.
    Fleischman, Angela G.
    BLOOD, 2014, 124 (21)
  • [44] Characterization of response to toll-like receptor 9 agonist CpR-2252 in the mouse liver
    Makowska, Zuzanna
    La Monica, Nicola
    Kandimalla, Ekambar R.
    Heim, Markus H.
    SWISS MEDICAL WEEKLY, 2011, 141 : 6S - 6S
  • [45] Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4
    Takeuchi, Ario
    Kamiryou, Yoriyuki
    Yamada, Hisakata
    Eto, Masatoshi
    Shibata, Kensuke
    Haruna, Kennichi
    Naito, Seiji
    Yoshikai, Yasunobu
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (13-14) : 1562 - 1567
  • [46] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects
    Satoru Yanagisawa
    Akira Koarai
    Hisatoshi Sugiura
    Tomohiro Ichikawa
    Masae Kanda
    Rie Tanaka
    Keiichiro Akamatsu
    Tsunahiko Hirano
    Kazuto Matsunaga
    Yoshiaki Minakata
    Masakazu Ichinose
    Respiratory Research, 10
  • [47] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects
    Yanagisawa, Satoru
    Koarai, Akira
    Sugiura, Hisatoshi
    Ichikawa, Tomohiro
    Kanda, Masae
    Tanaka, Rie
    Akamatsu, Keiichiro
    Hirano, Tsunahiko
    Matsunaga, Kazuto
    Minakata, Yoshiaki
    Ichinose, Masakazu
    RESPIRATORY RESEARCH, 2009, 10
  • [48] Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells
    Li, Li
    Barry, Vivian
    Daffis, Stephane
    Niu, Congrong
    Huntzicker, Erik
    French, Dorothy M.
    Mikaelian, Igor
    Lanford, Robert E.
    Delaney, William E.
    Fletcher, Simon P.
    JOURNAL OF HEPATOLOGY, 2018, 68 (05) : 912 - 921
  • [49] Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator
    Lu, Ruolin
    Groer, Chad
    Kleindl, Peter A.
    Moulder, K. Ryan
    Huang, Aric
    Hunt, Jordan R.
    Cai, Shuang
    Aires, Daniel J.
    Berkland, Cory
    Forrest, M. Laird
    JOURNAL OF CONTROLLED RELEASE, 2019, 306 (165-176) : 165 - 176
  • [50] Toll-like receptor 7/8 agonist resiquimod induces late preconditioning in neonatal cardiac myocytes
    Yong-yi Wang
    Sha Liu
    Feng Lian
    Wen-gang Yang
    Song Xue
    Acta Pharmacologica Sinica, 2011, 32 : 565 - 572