An important source of uncertainty in finite element models used for static and fatigue analysis is due to inaccuracy in estimating both the magnitude and distribution of loads. Furthermore, it is often assumed in the models that the structure is rigidly supported even though there may be significant compliance at the support. It is often difficult to accurately estimate the compliance as well as the actual distribution of the load. Recent improvements in experimental techniques enable full-field strain measurement with relative ease for structural components. A method for using these measurements to compute the applied load and distribution, as well as compliances at the supported boundaries, is presented in this paper. Accurately determining the loads and boundary conditions can significantly improve the ability to predict fatigue life and the likely location of failure for structures.