2,3-Dihydro-1H-1,5-benzodiazepines: A conversion of thiolactams to amidines

被引：16
|
作者：
Puodziunaite, B [1 ]
Kosychova, L [1 ]
Janciene, R [1 ]
Stumbreviciute, Z [1 ]
机构：
[1] Lithuania Acad Sci, Inst Biochem, LT-2600 Vilnius, Lithuania
来源：
MONATSHEFTE FUR CHEMIE | 1997年 / 128卷 / 12期
关键词：
2,3-dihydro-1H-1,5-benzodiazepines; thiolactam; amidine;
D O I：
10.1007/BF00807260
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of a new series of diversely N-4 substituted amidines of 2,3-dihydro-1H-1,5-benzodiazepine has been accomplished starting from tetrahydro-1,5-benzodiazepin-2-one derivatives. These compounds were transformed into the desired thiolactams 2a-i which reacted in the presence of mercuric chloride with ammonia, as well as primary or secondary amines to give amidines 3a-i. Hydrazidines 3j-1 were prepared by treatment of thiolactams with an excess of hydrazine.
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页码：1275 / 1281
页数：7
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