Regioselective C3 Alkenylation of 4H-pyrido[1,2-a] pyrimidin-4-ones via Palladium-Catalyzed C-H Activation

被引：27
|
作者：
Liu, Wenjie [1 ]
Wang, Shaohua [1 ]
Zhang, Qi [1 ]
Yu, Jingwen [1 ]
Li, Jiahe [1 ]
Xie, Zhiwei [1 ]
Cao, Hua [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 09期
基金：
中国国家自然科学基金;
关键词：
alkenylation; C-H activation; homogeneous catalysis; palladium; regioselectivity; EFFLUX PUMP INHIBITORS; PALLADIUM(II)-CATALYZED DIRECT ALKENYLATION; DIRECT OXIDATIVE ALKENYLATION; PSEUDOMONAS-AERUGINOSA; DEHYDROGENATIVE ALKENYLATION; INTERMOLECULAR ALKENYLATION; BOND FUNCTIONALIZATION; DIRECT ARYLATION; INDOLES; OLEFINATION;
D O I：
10.1002/asia.201402455
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general and efficient palladium-catalyzed direct C3 alkenylation of 4H-pyridoA1,2-a] pyrimidin-4-ones using AgOAc/O-2 as the oxidant has been developed. A variety of 4H-pyrido[1,2-a] pyrimidin-4-ones were successfully coupled with acrylate esters, styrenes, methylvinylketone, and acrylamide in moderate to excellent yields. The reaction exhibited complete regio-and stereoselectivity. This transformation provides an attractive new approach to functionalize 4HpyridoACHTUNGTRENUNG[ 1,2-a] pyrimidin-4-ones.
引用
收藏
页码：2436 / 2439
页数：4
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