Regioselective C3 Alkenylation of 4H-pyrido[1,2-a] pyrimidin-4-ones via Palladium-Catalyzed C-H Activation

被引：27

作者：

Liu, Wenjie ^{[1
]}

Wang, Shaohua ^{[1
]}

Zhang, Qi ^{[1
]}

Yu, Jingwen ^{[1
]}

Li, Jiahe ^{[1
]}

Xie, Zhiwei ^{[1
]}

Cao, Hua ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 09期

基金：

中国国家自然科学基金;

关键词：

alkenylation; C-H activation; homogeneous catalysis; palladium; regioselectivity; EFFLUX PUMP INHIBITORS; PALLADIUM(II)-CATALYZED DIRECT ALKENYLATION; DIRECT OXIDATIVE ALKENYLATION; PSEUDOMONAS-AERUGINOSA; DEHYDROGENATIVE ALKENYLATION; INTERMOLECULAR ALKENYLATION; BOND FUNCTIONALIZATION; DIRECT ARYLATION; INDOLES; OLEFINATION;

D O I：

10.1002/asia.201402455

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and efficient palladium-catalyzed direct C3 alkenylation of 4H-pyridoA1,2-a] pyrimidin-4-ones using AgOAc/O-2 as the oxidant has been developed. A variety of 4H-pyrido[1,2-a] pyrimidin-4-ones were successfully coupled with acrylate esters, styrenes, methylvinylketone, and acrylamide in moderate to excellent yields. The reaction exhibited complete regio-and stereoselectivity. This transformation provides an attractive new approach to functionalize 4HpyridoACHTUNGTRENUNG[ 1,2-a] pyrimidin-4-ones.

引用

页码：2436 / 2439

页数：4

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