Polymeric Anti-HIV Therapeutics

被引：22
|
作者：
Danial, Maarten [1 ,2 ,3 ]
Klok, Harm-Anton [1 ,2 ]
机构：
[1] Ecole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland
[2] Inst Sci & Ingn Chim, Lab Polymeres, CH-1015 Lausanne, Switzerland
[3] CSIRO Mat Sci & Engn, Clayton, Vic 3168, Australia
来源：
MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 01期
关键词：
antiviral; HIV polymer therapeutics; inhibitor; microbicide; polyvalency; HUMAN-IMMUNODEFICIENCY-VIRUS; DEXTRAN SULFATE; DC-SIGN; ANTIRETROVIRAL THERAPY; RADICAL POLYMERIZATION; ENVELOPE GLYCOPROTEIN; IN-VITRO; SYNTHETIC PEPTIDE; CRYSTAL-STRUCTURE; DENDRITIC CELLS;
D O I：
10.1002/mabi.201400298
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti-HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC-SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti-HIV therapeutics.
引用
收藏
页码：9 / 35
页数：27
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