Construction of a two-photon fluorescent turn-on probe for hydrogen persulfide and polysulfide and its bioimaging application in living mice

被引：61
|
作者：
Shang, Huiming [1 ]
Chen, Hua [2 ]
Tang, Yonghe [1 ]
Guo, Rui [2 ]
Lin, Weiying [1 ,2 ]
机构：
[1] Univ Jinan, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China
[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 230卷
关键词：
Two-photon; Fluorescent probes; Fluorescence sensing; Tissues; Hydrogen persulfide and polysulfide; IN-VIVO; OXIDATIVE STRESS; BIOLOGICAL-SYSTEMS; DESIGN STRATEGIES; LIVE CELLS; SULFIDE; SUPEROXIDE; AGGREGATION; CYSTEINE; TISSUES;
D O I：
10.1016/j.snb.2016.02.124
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Intense biological studies have indicated that the biological functions associated with hydrogen sulfide may actually be mediated by H2Sn (n > 1). Therefore, it is necessary to construction small-molecule fluorescent probe for the visualization of concentration of H2Sn (n > 1) in living systems. Here, we described a novel two-photon fluorescent turn-on probe, GCTPOC-H2S2, for specific detection of H2Sn, and the probe displayed high selectivity and sensitivity to H2Sn. Furthermore, we demonstrated that the probe GCTPOC-H2S2 could be employed to in situ image of H2Sn in living mice for the first time. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：773 / 778
页数：6
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