Construction of a two-photon fluorescent turn-on probe for hydrogen persulfide and polysulfide and its bioimaging application in living mice

被引：61

作者：

Shang, Huiming ^{[1
]}

Chen, Hua ^{[2
]}

Tang, Yonghe ^{[1
]}

Guo, Rui ^{[2
]}

Lin, Weiying ^{[1
,2
]}

机构：

[1] Univ Jinan, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 230卷

关键词：

Two-photon; Fluorescent probes; Fluorescence sensing; Tissues; Hydrogen persulfide and polysulfide; IN-VIVO; OXIDATIVE STRESS; BIOLOGICAL-SYSTEMS; DESIGN STRATEGIES; LIVE CELLS; SULFIDE; SUPEROXIDE; AGGREGATION; CYSTEINE; TISSUES;

D O I：

10.1016/j.snb.2016.02.124

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Intense biological studies have indicated that the biological functions associated with hydrogen sulfide may actually be mediated by H2Sn (n > 1). Therefore, it is necessary to construction small-molecule fluorescent probe for the visualization of concentration of H2Sn (n > 1) in living systems. Here, we described a novel two-photon fluorescent turn-on probe, GCTPOC-H2S2, for specific detection of H2Sn, and the probe displayed high selectivity and sensitivity to H2Sn. Furthermore, we demonstrated that the probe GCTPOC-H2S2 could be employed to in situ image of H2Sn in living mice for the first time. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：773 / 778

页数：6

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