Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes

被引：10

作者：

Chand, S. Sarath ^{[1
,2
]}

Gopalan, Greeshma ^{[1
,2
]}

Santhini, P. V. ^{[1
,2
]}

Preethanuj, P. ^{[2
]}

John, Jubi ^{[2
]}

Harakat, Dominique ^{[3
]}

Jaroschik, Florian ^{[3
]}

Radhakrishnan, K. V. ^{[1
,2
]}

机构：

[1] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India

[2] Natl Inst Interdisciplinary Sci & Technol CSIR, Organ Chem Sect, Trivandrum 695019, Kerala, India

[3] Univ Reims, Inst Chim Mol Reims CNRS UMR 7312, F-51687 Reims 2, France

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 05期

关键词：

H BOND ACTIVATION; INTERMOLECULAR HYDROARYLATION; CATIONIC POLYFULVENES; 6+3 CYCLOADDITION; INDOLE SYNTHESIS; FACILE SYNTHESIS; AROMATIC IMINES; METAL-COMPLEXES; DOMINO REACTION; FULVENES;

D O I：

10.1021/acs.orglett.6b00047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diverse approach toward the catalytic regioselective nucleophilic addition of nitrogen heterocycles to Lewis acid activated pentafulvenes has been established. The developed protocol introduces pentafulvenes as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing alkylidenecyclopentenylation at the C-3 position of indoles and the C-2 position of pyrrole.

引用

页码：964 / 967

页数：4

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