Synthesis, DNA binding and cytotoxic evaluation of aminoquinoline scaffolds

被引：7
|
作者：
Kumar, Gopal Senthil [1 ]
Ali, Mohamed Ashraf [2 ,3 ,4 ]
Choon, Tan Soo [2 ]
Prasad, Karnam Jayarampillai Rajendra [1 ]
机构：
[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India
[2] Univ Sains Malaysia, Inst Res Mol Med, Minden 11800, Penang, Malaysia
[3] Alwar Pharm Coll, Dept Med Chem, New Drug Discovery Res, Alwar 301030, Rajasthan, India
[4] Sunrise Univ, Dept Med Chem, New Drug Discovery Res, Alwar 301030, Rajasthan, India
来源：
JOURNAL OF CHEMICAL SCIENCES | 2016年 / 128卷 / 03期
关键词：
Hydrazinylquinolines; Isoindolin-1,3-diones; DNA binding; cytotoxicity; ANTITUMOR-ACTIVITY; PHTHALIMIDE; CHLOROQUINE; DERIVATIVES; QUINOLINES; GROWTH; DRUG;
D O I：
10.1007/s12039-015-1025-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An effortless synthetic route has been developed for the synthesis of a new class of aminoquinoline substituted isoindolin-1,3-diones from regio-isomerical hydrazinylquinolines with phthalic anhydride in presence of Eaton's reagent. DNA binding studies of selected isomeric compounds showed interaction with DNA via intercalation mode with higher binding affinity of 4-substituted quinolines rather than 2-substituted counterparts. Further, all compounds were screened for cytotoxic activity against three human cancer cell lines, among them compound 2c outranged standard doxorubicin against CCRF-CEM cell line.
引用
收藏
页码：391 / 400
页数：10
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