Synthesis, DNA binding and cytotoxic evaluation of aminoquinoline scaffolds

被引：7

作者：

Kumar, Gopal Senthil ^{[1
]}

Ali, Mohamed Ashraf ^{[2
,3
,4
]}

Choon, Tan Soo ^{[2
]}

Prasad, Karnam Jayarampillai Rajendra ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India

[2] Univ Sains Malaysia, Inst Res Mol Med, Minden 11800, Penang, Malaysia

[3] Alwar Pharm Coll, Dept Med Chem, New Drug Discovery Res, Alwar 301030, Rajasthan, India

[4] Sunrise Univ, Dept Med Chem, New Drug Discovery Res, Alwar 301030, Rajasthan, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2016年 / 128卷 / 03期

关键词：

Hydrazinylquinolines; Isoindolin-1,3-diones; DNA binding; cytotoxicity; ANTITUMOR-ACTIVITY; PHTHALIMIDE; CHLOROQUINE; DERIVATIVES; QUINOLINES; GROWTH; DRUG;

D O I：

10.1007/s12039-015-1025-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An effortless synthetic route has been developed for the synthesis of a new class of aminoquinoline substituted isoindolin-1,3-diones from regio-isomerical hydrazinylquinolines with phthalic anhydride in presence of Eaton's reagent. DNA binding studies of selected isomeric compounds showed interaction with DNA via intercalation mode with higher binding affinity of 4-substituted quinolines rather than 2-substituted counterparts. Further, all compounds were screened for cytotoxic activity against three human cancer cell lines, among them compound 2c outranged standard doxorubicin against CCRF-CEM cell line.

引用

页码：391 / 400

页数：10

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