A prospective, single-blind randomised study on the effect of intercostal nerve protection on early post-thoracotomy pain relief

被引:22
|
作者
Wu, Nan [1 ]
Yan, Shi [1 ]
Wang, Xiaofei [1 ]
Lv, Chao [1 ]
Wang, Jia [1 ]
Zheng, Qingfeng [1 ]
Feng, Yuan [1 ]
Yang, Yue [1 ]
机构
[1] Peking Univ, Dept Thorac Surg 2, Key Lab Carcinogenesis & Translat Res, Sch Oncol,Beijing Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China
关键词
Intercostal nerve; Pain; Post-thoracotomy; POSTOPERATIVE PAIN;
D O I
10.1016/j.ejcts.2009.11.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Intracostal suture or intercostal muscle flap can reduce post-thoracotomy pain through the preservation of intercostal nerves below or above the incision. This study aims to test whether combining intracostal suture with intercostal muscle flap might achieve better pain relief than intracostal suture alone. Methods: This study included 144 consecutive patients who underwent pulmonary resection. Eighty patients entered the trial but eight were excluded. Seventy-two patients were randomly assigned to a muscle flap group, in which the fifth intercostal muscle and neurovascular bundle were raised and intracostal suture on the sixth rib was applied. For the control group, only intracostal suturing on the sixth rib was done. All patients had a functional epidural placed, which were removed 24 h after surgery. Differences on average numeric rating scale (aNRS) scores were assessed in an early post-operative period from day 1 to day 7 and a later period from week 2 to week 12, when patients were resting or coughing. The doses of oxycodone demand and hyperalgesia-related intercostal dermatomes (HIDs) were recorded for analysis. Results: No differences were noted between the two groups in terms of length and width of the incision, or duration of rib retraction. Neither in different time periods (early or late) nor the activity status (while resting or coughing) yielded a statistical difference on aNRS scores between the muscle flap group and the control group (muscle flap group vs control group: mean (95% confidence intervals) from d ay 1 to day 7, 4.42 (1.56-7.28) vs 4.79 (2.03-7.55) on coughing (p = 0.282); median (inter-quartile range, IQR) from day 1 to day 7, 1.71(0.86-3) vs 2.50 (1.16-3.12) while resting (p = 0.279); median (IQR) from week 2 to week 12, 0.43 (0-0.86) vs 0.48 (0.06-1.20) on coughing (p = 0.595); median (IQR) from week 2 to week 12, 0 (0-0.14) vs 0.05 (0-0.14) while resting (p = 0.856)). No differences were found in total oxycodone consumption from day 1 to day 7 between the two groups (Z = 1.821, p = 0.069). The rate of HIDs in each intercostal space and median number of HIDs were similar between the two groups on day 1 (p > 0.05) and day 7 (p > 0.05). Conclusions: The combination of intracostal suture with intercostal muscle flap may not necessarily achieve better post-thoracotomy pain control than using intracostal suture alone. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:840 / 845
页数:6
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