Enantioselective addition of phenyl and alkyl acetylenes to imines catalyzed by chiral Cu(I) complexes

被引：69
|
作者：
Benaglia, M [1 ]
Negri, D [1 ]
Dell'Anna, G [1 ]
机构：
[1] Politecn Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 47期
关键词：
propargyl amines; chiral bis-imines; acetylenes addition; chiral ligands; asymmetric catalysis;
D O I：
10.1016/j.tetlet.2004.09.138
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereoselective addition of phenyl acetylene and alkyl acetylenes to imines, catalyzed by chiral bis-imines-Cu(1) complexes was studied. A very simple experimental procedure allowed to obtain at room temperature optically active propargyl amines in very good yields and enantioselectivity up to 81%. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8705 / 8708
页数：4
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