Opiate drugs and opioid peptides differ in their effects on intracellular signalling, in which following ligand–receptor binding and internalization, opioids continue to signal from endosomes, whereas opiates activate receptors located at the Golgi.
机构:
Watson Sch Biol Sci, Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USAWatson Sch Biol Sci, Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA