A preclinical assessment of afatinib-treated HER2(+) gastric malignancies using Zr-89 trastuzumab

被引:0
|
作者
Viola-Villegas, Nerissa [1 ]
Janjigian, Yelena [2 ]
Gomes-DaGama, Erica [2 ]
Holland, Jason [1 ]
de Stanchina, Elisa [3 ]
Lewis, Jason [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Radiol, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Med, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Antitumor Assessment Core Facil, New York, NY 10021 USA
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
1105
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Correction to: Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer
    Shusuke Yagi
    Takeru Wakatsuki
    Noriko Yamamoto
    Keisho Chin
    Daisuke Takahari
    Mariko Ogura
    Takashi Ichimura
    Izuma Nakayama
    Hiroki Osumi
    Eiji Shinozaki
    Mitsukuni Suenaga
    Junko Fujisaki
    Yuichi Ishikawa
    Kensei Yamaguchi
    Ken Namikawa
    Yusuke Horiuchi
    Gastric Cancer, 2019, 22 : 526 - 526
  • [32] ImmunoPET with 89Zr-DFO-trastuzumab: Monitoring the pharmacodynamic effects on HER2/neu expression by Hsp90 inhibition in vivo
    Holland, Jason P.
    Caldas-Lopes, Eloisi
    Divilov, Vadim
    Longo, Valerie A.
    Taldone, Tony
    Zatorska, Danuta
    Chiosis, Gabriela
    Lewis, Jason S.
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [33] A general method for site-specific labeling of antibodies with 89Zr: improved immuno-reactivity and tumor retention of 89Zr-trastuzumab in a HER2 positive xenograft mouse model
    Kristensen, Lotte
    Christensen, Camilla
    Knudsen, Camilla
    Jensen, Mette
    Agnew, Brian
    Kjaer, Andreas
    Nielsen, Carsten
    JOURNAL OF NUCLEAR MEDICINE, 2017, 58
  • [34] Quantitative measurement of HER2 levels by multiplexed mass spectrometry to predict survival in gastric cancer patients treated with trastuzumab.
    Ock, Chan-Young
    An, Eunkyung
    Oh, Do-Youn
    Kim, Tae-Yong
    Lee, Kyung-Hun
    Han, Sae-Won
    Im, Seock-Ah
    Kim, Tae-You
    Liao, Wei-Li
    Cecchi, Fabiola
    Blackler, Adele
    Thyparambil, Sheeno P.
    Hoos, William Arthur
    Kim, Woo Ho
    Burrows, Jon
    Hembrough, Todd A.
    Bang, Yung-Jue
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [35] Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT
    Ulaner, Gary A.
    Hyman, David M.
    Ross, Dara S.
    Corben, Adriana
    Chandarlapaty, Sarat
    Goldfarb, Shari
    McArthur, Heather
    Erinjeri, Joseph P.
    Solomon, Stephen B.
    Kolb, Hartmuth
    Lyashchenko, Serge K.
    Lewis, Jason S.
    Carrasquillo, Jorge A.
    JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (10) : 1523 - 1528
  • [36] 89Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft
    Munnink, Thijs H. Oude
    de Korte, Maarten A.
    Nagengast, Wouter B.
    Timmer-Bosscha, Hetty
    Schroder, Carolina P.
    de Jong, Johan R.
    van Dongen, Guus A. M. S.
    Jensen, Michael Rugaard
    Quadt, Cornelia
    Lub-de Hooge, Marjolijn N.
    de Vries, Elisabeth G. E.
    EUROPEAN JOURNAL OF CANCER, 2010, 46 (03) : 678 - 684
  • [37] PI3K upregulation as a negative predictive factor of survival in HER2 amplified gastric cancer treated with Trastuzumab.
    Diaz-Serrano, Asuncion
    Lopez-Rios, Fernando
    Dominguez, Carolina
    Fonseca, Paula J.
    Angulo, Barbara
    Cid, Roberto A. Pazo
    Plaza, Carlos
    Rivera, Fernando
    Rodriguez, Margarita
    Leon, Ana
    Prieto, Susana Hernandez
    Paz-Ares, Luis
    Gomez-Martin, Carlos
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [38] Mucolytic agents can enhance HER2 receptor accessibility for 89Zr-trastuzumab, improving HER2-imaging in a mucin-overexpressing breast cancer xenograft mouse model
    Wimana, Zena
    Gebhart, Geraldine
    Guiot, Thomas
    Vanderlinden, Bruno
    Morandini, Renato
    Doumont, Gilles
    Van Simaeys, Gaetan
    Goldman, Serge
    Ghanem, Ghanem
    Flamen, Patrick
    JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (03)
  • [39] Trastuzumab Combined with Docetaxel-Based Regimens in Previously Treated Metastatic Gastric Cancer Patients with HER2 Over-Expression
    Dai, Guang-Hai
    Shi, Yan
    Chen, Li
    Lv, Ya-Li
    Zhong, Mei
    HEPATO-GASTROENTEROLOGY, 2012, 59 (120) : 2439 - 2444
  • [40] Mucolytic drug N-Acetylcystein improves 89Zr-trastuzumab HER2-immunoPET imaging by restoring accessibility to HER2 hampered by membrane mucin overexpression in a HER2 positive MUC4 overexpressing xenograft mouse model
    Wimana, Zena
    Gebhart, Geraldine
    Morandini, Renato
    Flamen, Patrick
    Ghanem, Ghanem
    CANCER RESEARCH, 2014, 74 (19)