Kidney organoid research: current status and applications

被引：14
|
作者：
Trush, Olena [1 ]
Takasato, Minoru [1 ,2 ,3 ]
机构：
[1] RIKEN, Lab Human Organogenesis, Ctr Biosyst Dynam Res, Kobe, Hyogo 6500047, Japan
[2] Kyoto Univ, Grad Sch Biostudies, Dept Anim Dev & Physiol, Lab Mol Cell Biol & Dev, Kyoto 6068501, Japan
[3] Osaka Univ, Grad Sch Med, Dept Dev & Regenerat, Suita, Osaka 5650871, Japan
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2022年 / 75卷
关键词：
BRANCHING MORPHOGENESIS; NEPHRON PROGENITORS; GENERATION; REVEALS; DISEASE; ORIGIN;
D O I：
10.1016/j.gde.2022.101944
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Organoids are being widely introduced as novel research models in multiple research fields. Human-induced pluripotent stem cells-derived kidney organoids became an indispensable tool to study human kidney development, model various diseases and infections leading to kidney damage, and offer a new route towards better drug development and validation, personalized drug screening, and regenerative medicine. In this review, we provide an update of the most recent developments in kidney organoid induction: their main goals, advantages, and shortcomings. We further discuss their current applications in providing modeling and treatment avenues to various kidney injuries, their use in genome-wide screening of kidney diseases, and the cell interactions occurring in these kidney structures.
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收藏
页数：13
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