Diffusion-derived parameters in lesions, peri-lesion, and normal-appearing white matter in multiple sclerosis using tensor, kurtosis, and fixel-based analysis

被引:8
|
作者
van der Weijden, Chris Wj [1 ]
van der Hoorn, Anouk [2 ]
Potze, Jan Hendrik [2 ]
Renken, Remco J. [3 ]
Borra, Ronald J. H. [1 ]
Dierckx, Rudi A. J. O. [1 ]
Gutmann, Ingomar W. [4 ]
Ouaalam, Hakim [5 ]
Karimi, Davood [6 ,7 ]
Gholipour, Ali [5 ,6 ,7 ,8 ]
Warfield, Simon K. [5 ,6 ,7 ]
de Vries, Erik F. J. [1 ]
Meilof, Jan F. [3 ,9 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Nucl Med & Mol Imaging, Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Radiol, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Groningen, Netherlands
[4] Univ Vienna, Fac Phys, Vienna, Austria
[5] Boston Childrens Hosp, Computat Radiol Lab, Boston, MA USA
[6] Boston Childrens Hosp, Dept Radiol, Boston, MA USA
[7] Harvard Med Sch, Boston, MA 02115 USA
[8] Boston Childrens Hosp, Intelligent Med Imaging Res Grp, Boston, MA USA
[9] Martini Ziekenhuis, Dept Neurol, Groningen, Netherlands
来源
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2022年 / 42卷 / 11期
关键词
Axonal integrity; diffusion kurtosis imaging; diffusion tensor imaging; fixel-based analysis; multiple sclerosis; GAUSSIAN WATER DIFFUSION; TRAUMATIC BRAIN-INJURY; DISTORTION CORRECTION; FIBER DENSITY; DAMAGE; QUANTIFICATION; FRAMEWORK; MOVEMENT; IMAGES; TRACT;
D O I
10.1177/0271678X221107953
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neuronal damage is the primary cause of long-term disability of multiple sclerosis (MS) patients. Assessment of axonal integrity from diffusion MRI parameters might enable better disease characterisation. 16 diffusion derived measurements from diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and fixel-based analysis (FBA) in lesions, peri-lesion and normal appearing white matter were investigated. Diffusion MRI scans of 11 MS patients were processed to generate DTI, DKI, and FBA images. Fractional anisotropy (FA) and fibre density (FD) were used to assess axonal integrity across brain regions. Subsequently, 359 lesions were identified, and lesion and peri-lesion segmentation was performed using structural T(1)w, T(2)w, T(2)w-FLAIR, and T(1)w post-contrast MRI. The segmentations were then used to extract 16 diffusion MRI parameters from lesion, peri-lesion, and contralateral normal appearing white matter (NAWM). The measurements for axonal integrity, DTI-FA, DKI-FA, FBA-FD, produced similar results. All diffusion MRI parameters were affected in lesions as compared to NAWM (p < 0.001), confirming loss of axonal integrity in lesions. In peri-lesions, most parameters, except FBA-FD, were also significantly different from NAWM, although the effect size was smaller than in lesions. The reduction in axonal integrity in peri-lesions, despite unaffected fibre density estimates, suggests an effect of Wallerian degeneration.
引用
收藏
页码:2095 / 2106
页数:12
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