Evaluation of DMSO effects on cell electrical parameters using dielectrophoresis

被引:0
|
作者
Tivig, I [1 ]
Vallet, L. [2 ]
Moisescu, M. G. [1 ]
Radu, M. [3 ]
Savopol, T. [1 ]
Mir, L. M. [2 ]
机构
[1] Carol Davila Univ Med & Pharm, Biophys & Cellular Biotechnol Res Excellence Ctr, Biophys & Cellular Biotechnol Dept, 8 Eroii Sanit Blvd,Sect 5, Bucharest 050474, Romania
[2] Univ Paris Saclay, CNRS, Gustave Roussy, Metab & Syst Aspects Oncogcnesis METSY, F-94805 Villejuif, France
[3] Horia Hulubei Natl Inst Phys & Nucl Engn, Dept Life & Environm Phys, Reactorului 30, Magurele 077125, Romania
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中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Mouse fibroblasts were exposed to buffers containing various concentrations of DMSO and dielectrophoretic spectra were acquired. Based on these spectra, electric parameters of the cell (cytosol conductivity, membrane conductivity and membrane permittivity) were computed. A decrease of all electrical parameters was observed with the increase of the DMSO concentration. Results were analyzed in terms of DMSO perturbation of the structured water layers adjacent to the membrane and of lipid packing.
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页数:3
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