Volumetric monitoring of aqueous two phase system droplets using time-lapse optical coherence tomography

被引：5

作者：

Lee, J. ^{[1
]}

Bathany, C. ^{[2
]}

Ahn, Y. ^{[3
,4
]}

Takayama, S. ^{[2
]}

Jung, W. ^{[1
,5
]}

机构：

[1] UNIST, Dept Biomed Engn, Ulsan 44919, South Korea

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea

[4] Ctr Marine Integrated Biomed Technol, Busan 48513, South Korea

[5] IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea

来源：

LASER PHYSICS LETTERS | 2016年 / 13卷 / 02期

关键词：

optical coherence tomography; aqueous two phase system; droplet; microfluidics;

D O I：

10.1088/1612-2011/13/2/025606

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a volumetric monitoring method to observe the morphological changes of aqueous two phase system (ATPS) droplets in a microfluidic system. Our method is based on time-lapse optical coherence tomography (OCT) which allows the study of the dynamics of ATPS droplets while visualizing their 3D structures and providing quantitative information on the droplets. In this study, we monitored the process of rehydration and deformation of an ATPS droplet in a microfluidic system and quantified the changes of its volume and velocity under both static and dynamic fluid conditions. Our results indicate that time-lapse OCT is a very promising tool to evaluate the unprecedented features of droplet-based microfluidics.

引用

页数：5

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