New DNA Methylation Inhibitors Based on 1,2,4-Triazole Thioether Derivatives

被引：4

作者：

Hovsepyan, T. R. ^{[1
]}

Dilanyan, S. V. ^{[1
]}

Minasyan, N. S. ^{[2
]}

Arsenyan, F. G. ^{[1
]}

Nersesyan, L. E. ^{[1
]}

Agaronyan, A. S. ^{[1
]}

Danielyan, I. S. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Mnjoyan Inst Fine Organ Chem, Sci & Technol Ctr Organ & Pharmaceut Chem, Pr Azatutyan 26, Yerevan 0014, Armenia

[2] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Mol Struct Res Ctr, Yerevan, Armenia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 07期

关键词：

1,2,4-triazoles; thione-thiol tautomerism; thioether group; sarcoma-180; DNA methylation;

D O I：

10.1134/S1070363218070071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New 4-substituted 4H-1,2,4-triazole-3-thiol derivatives were synthesized by introducing benzylsulfanylethyl groups in the 5-position of the heterocycle. Alkylation of the thiol group provides additional pharmacophore thioether, carboxamide, carboxyl, and hydroxyethyl fragments. Regardless of the nature of the substituents in the position 5 aminomethylation and cyanoethylation proceed at the N-2 atom. The synthesized compounds were studied for anti-tumor activity and the effect on the methylation level of tumor DNA.

引用

页码：1390 / 1396

页数：7

共 50 条

[21] EQUILIBRIUM SPECTRA AND STRUCTURE OF 1,2,4-TRIAZOLE DERIVATIVES .5. 3-AZIDO-1,2,4-TRIAZOLE DERIVATIVES
MELNIKOV, VV
BAEVA, LF
STOLPAKO.VV
PEVZNER, MS
MARTYNOV.MN
GIDASPOV, BV
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1974, (09): : 1283 - 1287
[22] Synthesis and Characterization of Some New Indoline-Based 1,2,4-Triazole Derivatives
Afshar, N.
Hatamjafari, F.
Shiroudi, A.
Pourshamsian, K.
Oliaey, A. R.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (12) : 2153 - 2158
[23] Synthesis and Characterization of Some New Indoline-Based 1,2,4-Triazole Derivatives
N. Afshar
F. Hatamjafari
A. Shiroudi
K. Pourshamsian
A. R. Oliaey
Russian Journal of Organic Chemistry, 2020, 56 : 2153 - 2158
[24] Synthesis and antitumor effects of a new class of 1,2,4-triazole derivatives
Wu, Zheng
Li, Xin
Chi, Chun-Lan
Xu, Lu
Sun, Yong-Yue
Chen, Bao-Quan
MEDICINAL CHEMISTRY RESEARCH, 2021, 30 (01) : 142 - 151
[25] Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Desai, Shobha
Laddi, Umesh
Bennur, Rajani
Bennur, Shankar
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2013, 52 (08): : 1176 - 1181
[26] Synthesis and antitumor effects of a new class of 1,2,4-triazole derivatives
Zheng Wu
Xin Li
Chun-Lan Chi
Lu Xu
Yong-Yue Sun
Bao-Quan Chen
Medicinal Chemistry Research, 2021, 30 : 142 - 151
[27] Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Guemruekcueoglu, Nurhan
Serdar, Mevlut
Celik, Elif
Sevim, Ali
Demirbas, Neslihan
TURKISH JOURNAL OF CHEMISTRY, 2007, 31 (03) : 335 - 348
[28] Synthesis of New 1,2,4-Triazole Derivatives with Expected Biological Activities
Abdulghani, Shamsalmiluk Mohammed
Al-Rawi, Muna Sameer
Tomma, Jumbad Hermiz
CHEMICAL METHODOLOGIES, 2022, 6 (01): : 59 - 66
[29] Synthesis of some new 1,2,4-triazole derivatives by Mitsunobu chemistry
Alizadeh, A
HELVETICA CHIMICA ACTA, 2005, 88 (10) : 2777 - 2780
[30] Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bayrak, Hacer
Demirbas, Ahmet
Bektas, Hakan
Karaoglu, Sengul Alpay
Demirbas, Neslihan
TURKISH JOURNAL OF CHEMISTRY, 2010, 34 (06) : 835 - 846

← 1 2 3 4 5 →