HIV-1 vaccine candidate evaluation in non-human primates

被引：7
|
作者：
Lu, YC [1 ]
机构：
[1] Inst Int Vaccine Dev Inc, Cambridge, MA 02138 USA
来源：
CRITICAL REVIEWS IN ONCOGENESIS | 1997年 / 8卷 / 2-3期
关键词：
AIDS vaccine efficacy; HIV-1 vaccine candidates; non-human primates; animal models; recombinant HIV-1 gp120; whole inactivated virus; recombinant viral vectors; recombinant BCG vectors;
D O I：
10.1615/CritRevOncog.v8.i2-3.50
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of an HIV-1 vaccine in the last 13 years from an industrial point of view has focused on evaluating potential vaccine candidates in non-human primates. This review discusses the HIV-1 vaccine candidates that have been tested in chimpanzees or monkeys and includes those based on recombinant gp120, recombinant gp160, different viral and bacterial vectors expressing gp120, gp160, or only V3 peptide, naked DNA vaccines, and whole inactivated viruses. To help understand the result of efficacy studies in chimpanzees and monkeys, information regarding the challenge viruses used in these studies is also included. The review does not discuss the testing of SIV-related vaccines or the testing of HIV-1 vaccine candidates in other animal species other than non-human primates.
引用
收藏
页码：273 / 291
页数：19
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