DNA Based Vaccines against Tuberculosis; Recent Progress and Discovery Research in Vaccine Development and Delivery System

Tuberculosis is believed to be one of the leading sources of death round the world; nevertheless, Bacillus Calmette Guerin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine on children, its efficiency remains under question in adults. We conducted the present study to provide an overview of the DNA based vaccine against Tuberculosis (TB) and highlight the vaccine delivery advances and limitations in TB treatment. This study also aimed to bring a review of mycobacterial antigens, including heat shock protein 65 (Hsp65), antigen 85A (Ag85A), early secretory antigenic target (EAST-6), antigen 85B (Ag85B), and heat shock protein X (HspX) as the most extensively considered antigens used to strategy vaccines against M. tuberculosis.