Synthesis and spectroscopic studies of 3-carbamoylisonicotinic acid derivatives

被引：8

作者：

Ershov, Oleg, V ^{[1
]}

Ievlev, Mikhail Yu ^{[1
]}

Belikov, Mikhail Yu ^{[1
]}

Fedoseev, Sergey, V ^{[1
]}

机构：

[1] Ulyanov Chuvash State Univ, Moskovsky Pr 15, Cheboksary 428015, Russia

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 22期

关键词：

Cyano group; Nitriles; Hydrolysis; Carboxylic acid; Isonicotinic acid; Pyridone; MYCOBACTERIUM-TUBERCULOSIS; CITRIC-ACID; HYDROLYSIS; NITRILES; 2-OXO-1,2-DIHYDROPYRIDINE-3,4-DICARBONITRILES; FLUORESCENCE; ANTAGONISTS; INHIBITORS; SERIES; SAR;

D O I：

10.1016/j.tetlet.2018.04.067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual example of the selective hydrolysis of a cyano group to the corresponding carboxyl group under mild reaction conditions in the presence of a carboxamide group is reported. The reaction resulted in the formation of a rare combination of vicinal carboxamide and carboxyl groups on a pyridone ring. The structure of the synthesized products was thoroughly studied using one- and two-dimensional NMR experiments and the reaction pathway was monitored fluorometrically. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2189 / 2192

页数：4

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