Open questions in sweet, umami and bitter taste genetics

被引：7

作者：

Risso, Davide ^{[1
]}

Drayna, Dennis ^{[2
]}

Tofanelli, Sergio ^{[3
]}

Morini, Gabriella ^{[4
]}

机构：

[1] Soremartec Italia Srl, Ferrero Grp, Alba, CN, Italy

[2] NIDCD, NIH, Bethesda, MD 20892 USA

[3] Univ Pisa, Dept Biol, Via Ghini 13, I-56126 Pisa, Italy

[4] Univ Gastron Sci, Piazza Vittorio Emanuele 9, I-12042 Pollenzo, CN, Italy

来源：

CURRENT OPINION IN PHYSIOLOGY | 2021年 / 20卷

关键词：

D O I：

10.1016/j.cophys.2020.12.007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sweet, umami and bitter tastes are in large part mediated by G-protein coupled receptors of taste type 1 (TAS1R) and taste type 2 (TAS2R) families. The genetics and molecular function of TAS receptors has been extensively explored, but more recently studies have identified these receptors in extra-oral locations. This has opened new perspectives on the function and evolutionary role of these receptors, and given rise to the possibility of using them as targets for personalized health interventions. In addition, these findings have generated new questions about the genetics of TAS1Rs and TAS2Rs that await answers. Here, we address the questions that we consider to be the most salient and intriguing and suggest more comprehensive theoretical and experimental approaches that could help to solve them.

引用

页码：174 / 179

页数：6

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