Neuropsychiatric aspects of treated Wilson's disease

被引：78

作者：

Svetel, Marina ^{[1
]}

Potrebic, Aleksandra ^{[2
]}

Pekmezovic, Tanja ^{[3
]}

Tomic, Aleksandra ^{[1
]}

Kresojevic, Nikola ^{[1
]}

Jesic, Rada ^{[4
]}

Dragasevic, Natasa ^{[1
]}

Kostic, Vladimir S. ^{[1
]}

机构：

[1] CCS, Inst Neurol, Belgrade 11000, Serbia

[2] Clin Ctr Serbia, Inst Psychiat, Belgrade 11000, Serbia

[3] Sch Med, Inst Epidemiol, Belgrade, Serbia

[4] Clin Ctr Serbia, Inst Gastroenterol, Belgrade, Serbia

来源：

PARKINSONISM & RELATED DISORDERS | 2009年 / 15卷 / 10期

关键词：

Wilson's disease; Psychiatric symptoms; Neuropsychiatric inventory; PARKINSONS-DISEASE; GENE; DEPRESSION; PSYCHOPATHOLOGY; HUNTINGTONS; SYMPTOMS; DEMENTIA; ATPASE;

D O I：

10.1016/j.parkreldis.2009.01.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The objective of the current cross-sectional study was to use standardized psychiatric interviews (the Structured Clinical Interview for DSM-IV Axis I Disorders and the Neuropsychiatric Inventory; NPI) in order to better characterize psychiatric symptoms in 50 consecutive, treated and clinically stable patients with Wilson's disease (WD). Nine patients (18%) had one, 7 patients (14%) had two, and 20 (40%) had >= 3 neuropsychiatric symptoms present. The most often enclosed symptoms were anxiety (62%), depression (36%), irritability (26%), as well as disinhibition and apathy (24% each). Twenty two patients (44%) had a score >= 4 on at least one of the NPI items: again, most frequently anxiety (17 patients; 34%), depression (13 patients; 26%) and apathy (9 patients; 18%). Therefore, even among stable, long-term treated patients with WD approximately 70% experienced psychiatric symptoms. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：772 / 775

页数：4

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