Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate

被引：0
|
作者：
de Andrade, M [1 ]
Thiel, TJ [1 ]
Yu, LP [1 ]
Amos, CI [1 ]
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
来源：
GENETIC EPIDEMIOLOGY | 1997年 / 14卷 / 06期
关键词：
ascertainment; components of variance; linkage;
D O I：
10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We report results when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction. (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码：773 / 778
页数：6
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