Chemical composition, cytotoxicity and larvicidal activity against Aedes aegypti of essential oils from Vitex gardineriana Schauer

被引:0
|
作者
Pereira, Evaristo Jose P. [1 ]
Silva, Horlando C. [5 ]
Holanda, Carlos L. [2 ]
de Menezes, Jane Eire Silva A. [1 ,2 ]
Siqueira, Sonia Maria C. [1 ,2 ]
Rodrigues, Tigressa Helena S. [3 ]
Fontenelle, Raquel Oliveira S. [1 ,3 ]
do Vale, Jean Parcelli C. [3 ]
da Silva, Priscila T. [3 ]
Santiago, Gilvandete Maria P. [4 ,5 ]
Santos, Helcio S. [3 ]
机构
[1] Univ Estadual Ceara, Recursos Nat, Fortaleza, Ceara, Brazil
[2] Univ Estadual Ceara, Curso Quim, Itapipoca, CE, Brazil
[3] Univ Estadual Vale Acarau, Ctr Ciencias Exatas & Tecnol, Sobral, CE, Brazil
[4] Univ Fed Ceara, Dept Farm, Fortaleza, Ceara, Brazil
[5] Univ Fed Ceara, Dept Quim Organ & Inorgan, Fortaleza, Ceara, Brazil
来源
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2018年 / 17卷 / 03期
关键词
Vitex gardineriana; Essential oil; Larvicidal activity; Cytotoxicity; LEAVES; CONSTITUENTS; ANTIOXIDANT; REPELLENCY; FRUITS; DENGUE;
D O I
暂无
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Vitex gardneriana Schauer (Lamiaceae) popularly known as "jaramataia", is a shrub commonly found in caatinga biome located in Northeast Brazil. In folk medicine, its leaves have been used as analgesic and anti-inflammatory agents. The chemical composition of the essential oil from leaves obtained by hydrodistillation was analyzed and identified by GC-MS and GC-FID and showing a total of 26 constituents (95.9%) being 2 monoterpenes (0.4%) and 24 sesquiterpenes (95.4%). The main constituents identified were cis-calamenene (29.7%), 6,9-guaiadiene (14.5%) and caryophyllene oxide (14.0%). The essential oil has been demonstrated high larvicidal activity against Aedes aegypti (LC50 = 28.0 mu g/mL). In the evaluation of the bioassay with Artemia salina the essential oil showed LC50 = 98.11 mu g/mL. In addition, the essential oil did not show cytotoxicity (IC50 > 2.50 mg/mL) by the hemolysis assay.
引用
收藏
页码:302 / 308
页数:7
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