Piperidine alkaloids from Piper methysticum

被引：79
|
作者：
Dragull, K
Yoshida, WY
Tang, CS
机构：
[1] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA
[2] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA
来源：
PHYTOCHEMISTRY | 2003年 / 63卷 / 02期
关键词：
piper methysticum; Piperaceae; kava; awa; piperidine alkaloids; pipermethystine; 3; alpha; 4; alpha-epoxy-5; beta-pipermethystine; awaine;
D O I：
10.1016/S0031-9422(03)00111-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pipermethystine (1), 3alpha,4alpha-epoxy-5beta-pipermethystine (2) and awaine (3) were isolated from the aerial parts of kava (Piper methysticum G. Forster, Piperaccae) and identified by HRMS and NMR spectroscopic analysis. I was concentrated in the stem peelings and leaves. 2 and 3 are new alkaloids with 2 found only in cv. Isa among the 11 cultivars examined, and 3 occurred primarily in young leaves of all cultivars. The stem peelings have been used in recent years as a source of kavalactones in kava dietary supplement industry. Quantitative aspects of these piperidine alkaloids in P. methysticum and their potential activities on human physiology are discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：193 / 198
页数：6
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