Psoriasis Plays a Wild CARD

被引：3

作者：

Van Nuffel, Elien ^{[1
,2
]}

Afonina, Inna S. ^{[1
,2
]}

Beyaert, Rudi ^{[1
,2
]}

机构：

[1] VIB, Unit Mol Signal Transduct Inflammat, Ctr Inflammat Res, Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2018年 / 138卷 / 09期

关键词：

D O I：

10.1016/j.jid.2018.05.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14DE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis.

引用

页码：1903 / 1905

页数：4

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