Psoriasis Plays a Wild CARD

被引：3
|
作者：
Van Nuffel, Elien [1 ,2 ]
Afonina, Inna S. [1 ,2 ]
Beyaert, Rudi [1 ,2 ]
机构：
[1] VIB, Unit Mol Signal Transduct Inflammat, Ctr Inflammat Res, Ghent, Belgium
[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2018年 / 138卷 / 09期
关键词：
D O I：
10.1016/j.jid.2018.05.001
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14DE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis.
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页码：1903 / 1905
页数：4
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